Ottomans conquer the Mamluk Sultanate
Selim I defeats the Mamluks, annexing Syria, Egypt and the Hejaz and making the Ottomans the leading power of the Muslim world.
Selim I defeats the Mamluks, annexing Syria, Egypt and the Hejaz and making the Ottomans the leading power of the Muslim world.
Martin Luther publishes his Ninety-five Theses against indulgences, sparking the Protestant Reformation.
Spanish conquistadors under Hernán Cortés land on Mexico's Gulf Coast and found Villa Rica de la Vera Cruz, beginning the conquest of the Aztec Empire.
Suleiman I rules the Ottoman Empire at the height of its territorial, legal and cultural power.
Warriors led by the chieftain Lapulapu defeat Ferdinand Magellan's men on Mactan island; Magellan is killed.
Spanish forces under Hernán Cortés and their Indigenous allies capture the Aztec capital.
The ship Victoria under Juan Sebastián Elcano returns to Spain, completing the circumnavigation begun by Magellan.
Babur, using artillery and firearms, defeats Ibrahim Lodi, ending the Delhi Sultanate and founding the Mughal Empire.
Mạc Đăng Dung forces the Lê emperor to abdicate and founds the Mạc dynasty.
A small Spanish force led by Francisco Pizarro ambushes and captures the Inca emperor Atahualpa, beginning the fall of the Inca Empire.
Lê loyalists led by Nguyễn Kim enthrone Lê Trang Tông, beginning a long civil war between the restored Lê and the Mạc.
The English Parliament passes the Act of Supremacy, declaring Henry VIII Supreme Head of the Church of England and breaking with papal authority.
Francisco Pizarro founds Lima, which becomes the capital of the Spanish Viceroyalty of Peru.
Nicolaus Copernicus's On the Revolutions of the Heavenly Spheres is printed, placing the Sun at the centre and launching the Scientific Revolution.
Andreas Vesalius publishes his illustrated work on human anatomy based on direct dissection, founding modern anatomy.
The vast silver deposits of Cerro Rico at Potosí begin to be mined, supplying huge quantities of silver to Spain and the world economy.
An ecumenical council of the Catholic Church meets at Trent, reaffirming Catholic doctrine and launching the Counter-Reformation in response to Protestantism.
Ivan IV (Ivan the Terrible) is crowned in Moscow with the title of Tsar, marking the beginning of the Tsardom of Russia.
Mughal forces defeat Hemu, securing the throne of the young Akbar, whose reign brings the empire to its zenith.
Nguyễn Hoàng becomes governor of Thuận Hóa, laying the foundations of the Nguyễn lords' realm in the south.
William Shakespeare, the most celebrated playwright and poet in the English language, is born in Stratford-upon-Avon.
The Dutch provinces revolt against Spanish rule; the war ends with Spain recognising the independence of the Dutch Republic.
King Bayinnaung of Toungoo Burma captures Ayutthaya, making Siam a vassal within the largest empire in the history of mainland Southeast Asia.
The Kingdom of Poland and the Grand Duchy of Lithuania unite into a single federal state with a shared monarch and parliament.
Miguel López de Legazpi takes Manila and makes it the capital of the Spanish Philippines.
The fleet of the Holy League, formed by Spain, Venice and the Papacy, defeats the Ottoman navy in the Gulf of Patras.
Thousands of Huguenot Protestants are killed in Paris and other French cities during the French Wars of Religion.
Oda Nobunaga, who was unifying Japan, is betrayed by his general Akechi Mitsuhide and dies at Honnō-ji temple in Kyoto.
The Gregorian calendar takes effect in Catholic countries: Julian 4 October 1582 is followed by 15 October.
The Armada sent by Philip II to invade England is defeated by the English navy at the Battle of Gravelines and scattered during its retreat.
Toyotomi Hideyoshi twice invades Korea; Joseon and Ming forces, with Admiral Yi Sun-sin's navy, eventually repel the Japanese.
Lê–Trịnh forces under Trịnh Tùng recapture Thăng Long from the Mạc, who retreat to Cao Bằng.
Shah Abbas I moves the Safavid capital to Isfahan and builds the Naqsh-e Jahan Square and other celebrated monuments.
King Henry IV issues an edict granting substantial religious rights to the Huguenots, ending the French Wars of Religion.
Tokugawa Ieyasu defeats his rivals, paving the way for the Tokugawa shogunate's 250-year rule over Japan.
Queen Elizabeth I grants a royal charter to the East India Company, which later comes to rule much of the Indian subcontinent.
Jesuit missionary Matteo Ricci is permitted to reside in Beijing, becoming a bridge of science and culture between Europe and China.
Tokugawa Ieyasu is appointed shōgun and establishes his government at Edo, opening more than 250 years of Edo-period peace.
Miguel de Cervantes publishes the first part of Don Quixote, often regarded as one of the first modern novels.
Dutch captain Willem Janszoon aboard the Duyfken charted the west coast of Cape York Peninsula, the first recorded European landing in Australia.
English colonists establish Jamestown in Virginia, the first permanent English settlement in North America.
Samuel de Champlain founds Quebec on the St. Lawrence River, which becomes the centre of the colony of New France.
Johannes Kepler publishes Astronomia nova, stating his first two laws of planetary motion, including elliptical orbits.
Observing with his own telescope, Galileo Galilei discovers the moons of Jupiter, publishing them in Sidereus Nuncius in 1610 in support of heliocentrism.
An assembly of the land elects Michael Romanov as Tsar, ending the Time of Troubles; the Romanovs rule Russia until 1917.
Shakespeare dies in Stratford-upon-Avon, leaving some 39 plays and 154 sonnets.
Beginning with a revolt in Bohemia, the conflict spreads across Central Europe, drawing in the major European powers and causing enormous loss of life.
Jan Pieterszoon Coen of the Dutch East India Company seizes Jayakarta and founds Batavia (now Jakarta), the hub of Dutch power in Asia.
The Mayflower Pilgrims sign the Mayflower Compact and establish Plymouth Colony in Massachusetts.
A protracted war between the Trịnh lords in the north and the Nguyễn lords in the south ends with the country divided at the Gianh River.