Sargon founds the Akkadian Empire
Sargon of Akkad conquers the Sumerian city-states, creating the first known multi-ethnic empire in Mesopotamia.
Sargon of Akkad conquers the Sumerian city-states, creating the first known multi-ethnic empire in Mesopotamia.
A Babylonian and Median coalition sacks Nineveh, the Assyrian capital, marking the collapse of the Neo-Assyrian Empire.
Cyrus the Great takes Babylon, ending the Neo-Babylonian Empire; he later allows exiled Judeans to return to Judah.
Alexander the Great defeats Darius III, sealing the fall of the Achaemenid Empire.
Ardashir I defeats the last Parthian king, founding the Sasanian Empire, the last Iranian empire before the rise of Islam.
Rashidun forces defeat the Sasanian army in Iraq, opening the way to the capture of the capital Ctesiphon.
Husayn ibn Ali, grandson of Muhammad, is killed by Umayyad forces at Karbala, an event central to Shia Muslim memory.
Hulagu's Mongol army takes and devastates Baghdad, killing Caliph al-Musta'sim and ending the Abbasid Caliphate in Baghdad.
Neighbouring Arab states go to war with Israel; the war ends with the 1949 armistice agreements, and about 700,000 Palestinians flee or are expelled from their homes.
Saddam Hussein's Iraq invades Iran, beginning an eight-year war of attrition that kills hundreds of thousands.
Iraqi forces invade and occupy Kuwait, prompting UN sanctions and the formation of a US-led coalition.
A US-led coalition launches Operation Desert Storm, expelling Iraqi forces from Kuwait.
A US-led coalition invades Iraq and topples Saddam Hussein, beginning a long period of occupation and conflict.
The Islamic State group proclaims a 'caliphate' over territory seized in Iraq and Syria; it loses nearly all of it by 2017–2019.